The international break always provides a cause for concern for Premier League clubs as they lend their stars for duty.
After a busy week of national fixtures, a number of players have returned to their clubs with various niggles and strains.
With just four matches gone of the domestic season, the physio's workload is piling up as more and more are sidelined through injury.
And as matchday five approaches, some clubs have been left with an injury list as long as their arm.
Here's an update from the Physio Room on how your team is shaping up for this weekend's fixtures...
Arsenal - 6
Hector Bellerin (Knee) - 3 weeks
Konstantinos Mavropanos (Hip) - 3 weeks
Kieran Tierney (Hip) - 3 weeks
Joe Willock (Calf) - few days
Granit Xhaka (Achilles) - few days
Lucas Torreira (Impact injury) - unknown
Chelsea - 9
Ruben Loftus-Cheek (Achilles) - 8 weeks
Reece James (Ankle) - 2 weeks
Antonio Rudiger (Fatigue) - few days
N'golo Kante (Ankle) - few days
Pedro (Hamstring) - few days
Mateo Kovacic (Achilles) - few days
Callum Hudson-Odoi (Achilles) - few days
Marco van Ginkel (Knee) - unknown
Emerson (Hamstring) - unknown
Liverpool - 3
Naby Keita (Hip) - few days
Nathaniel Clyne (knee) - unknown
Alisson (Calf) - unknown
Man City - 6
Leroy Sane (Knee) - 6 months
Benjamin Mendy (Knee) - 10 days
John Stones (Thigh) - few days
Gabriel Jesus (Thigh) - few days
Ilkay Gundogan (Illness) - few days
Aymeric Laporte (Knee) - unknown
Man Utd - 8
Eric Bailly (Knee) - 14 weeks
Luke Shaw (Thigh) - 3 weeks
Diogo Dalot (Hip) - few days
Anthony Martial (Thigh) - few days
Paul Pogba (Ankle) - few days
Aaron Wan-Bissaka (Back) - few days
Jesse Lingard (Illness) - few days
Timothy Fosu-Mensah (Knee) - unknown
Tottenham - 6
Giovani Lo Celso (Hip) - 7 weeks
Juan Foyth (Ankle) - 3 weeks
Tanguy N'Dombele (Thigh) - few days
Kyle Walker-Peters (Thigh) - few days
Eric Dier (Hip) - few days
Ryan Sessegnon (Thigh) - few days