Jose Mourinho is in desperate need of a result back at his former home.
The Red Devils lost in this fixture last season thanks to an Alvaro Morata header.
This season United's slow start means failure to avoid defeat here would put Maurizio Sarri's side 10 points ahead of Mourinho.
Securing a draw at least would help ease the pressure on Mourinho, whilst the Blues will want to keep pace with Manchester City and Liverpool as surprise title contenders.
Eden Hazard continues to dazzle and show just why Real Madrid should have pursued him as the successor to Cristiano Ronaldo last summer.
Teams
Chelsea XI: Kepa; Azpilicueta, Rüdiger, Luiz, Alonso; Jorginho, Kanté, Kova?i?; Willian, Morata, Hazard
Chelsea subs: Caballero, Cahill, Zappacosta, Fabregas, Barkley, Pedro, Giroud
Man United XI: De Gea; Young, Lindelöf, Smalling, Shaw; Mati?, Pogba; Mata, Martial, Rashford; Lukaku
Man United subs: Romero, Bailly, Darmian, Andreas, Ander Herrera, Fred, Alexis