The Nairobi-Eldoret highway will be closed for heavy commercial trucks on Tuesday from 12pm to Wednesday 7pm during former President Daniel Moi's funeral.
Moi will be buried at his Kabarak home on Wednesday.
A memorial service will be held at Nyayo Stadium on Monday.
On Tuesday, Kenyans will observe a public holiday ahead of Moi’s state funeral.
Inspector-General of Police Hillary Mutyambai on Saturday said measures will be put in place to ensure free flow of traffic to Nyayo Stadium and Kabarak.
In Nairobi, Aerodome Road will be closed on Tuesday from 6am.
Uhuru Highway will be closed at the same time at Likoni, Bunyala, Valley Road and University Way Roundabout.
Traffic on the Nairobi-Malaba highway will be disrupted between Nairobi and Eldoret on February 11-12.
"All road users are advised to strictly adhere to the Highway Code to avert inconveniences," Mutyambai said at Jogoo House.
He added that there will be enhanced police department to ensure public safety and traffic control.
Mzee Moi died Tuesday morning at around 5.20am at the Nairobi Hospital where he was receiving treatment.
He was aged 95.
He was born in 1924 in Kabarak village, Baringo County.
Moi served as the second President of Kenya from 1978 to 2002.
President Uhuru Kenyatta eulogised him as one who served the nation with dignity and honour.
"One whose wisdom and diplomatic finesse kept Kenya, both relevant and neutral, even as the whole world was in the grips of the Cold War."
Moi became Kenya’s second Head of State in 1978 following the death of Kenya’s first President Mzee Jomo Kenyatta on August 22.
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