Precious Blood Kagwe Girls School was founded in February 1966 by the missionary sisters of Precious Blood, who were based in Lari constituency near Kiambu town.
When the school was started, it had 18 students under Sister Silvana, who stayed at the helm to steer it to still waters for five years. In 1970, the provincial inspector of schools Mr Grieves Cook declared it a harambee school before the first cohorts sat for their first East African Certificate Examination in 1971. Out of 21 candidates who sat for the exam, 18 passed.