Emotional Harry told Meghan "you look amazing, I missed you" as he saw her in her wedding dress for the first time.
The groom, 33, stood at the altar in St George's Chapel, Windsor, smiled as his bride walked towards him.
Meghan arrived accompanied by two page boys who held up her train as she made her way up the chapel's steps alone.
She is wearing a simple, long-sleeved white dress, with veil covering her face.
The royal bride entered the chapel by herself, to begin the walk down the alter, before being met by the Prince of Wales.
Prince Charles accompanied Meghan, 36, down the aisle in her father Thomas' absence while best man Prince William supported his brother.
Meghan spent her last night as an unmarried woman with her mum Doria Ragland at Cliveden House, roughly 10 miles from Windsor Castle.
Prince Harry stayed 15 miles away at Coworth Park with William.
Harry and Meghan announced their engagement to a flurry of excitement in November 2017, just days after Harry had popped the question over roast chicken.
Divorcee Meghan was baptised and confirmed into the Church of England ahead of her wedding day, with a small ceremony at the Chapel Royal in St James’s Palace in early March.
The Archbishop of Canterbury described it as "very special".