To reverse the slowdown in progress on Reproductive, Maternal, Newborn, Child, and Adolescent Health and Nutrition (RMNCAH&N) during the first half of the Sustainable Development Goals (SDGs) era, urgent and focused efforts are needed across five priority areas: placing a renewed focus on Sub-Saharan Africa, strengthening RMNCAH&N health systems, safeguarding gains amid crises, improving monitoring and accountability, and revitalizing political and financial commitment to RMNCAH&N.