A thrilling duel in perfect conditions saw Mutiso almost catch Kipruto with a late burst in the final metres of what was the closest finish in New York Marathon history.
Kipruto crossed the line in a time of two hours eight minutes and nine seconds, with Mutiso 0.16secs behind.
Kenya's Albert Korir, the 2021 New York winner, was third in 2:08:57.
READ MORE
Kenya is over-politicised while systems are routinely ignored
Kipyegon storms to victory in DL opener
Kenya basks in 10,000m glory at African Senior Athletics event
The paradox of success in Africa Forward Summit
Athena revels in her success at global showpiece
Delusion: When guests mistake African hospitality for hegemony
Nairobi to host mega Africa food finance summit as $100bn gap weighs on growth
Staff exits loom at DP Kindiki's office as Sh95m set for gratuity payments