A Suarez shot led to De Arrascaeta's opener and Suarez set up the second with a clever pass that De Arrascaeta volleyed in. After those two strikes, Uruguay thought it was on its way to the knockouts.
Ghana captain Andre Ayew, the team's only survivor from the 2010 squad, had his penalty saved by Sergio Rochet in the 21st minute and the game changed immediately after that. De Arrascaeta scored in the 26th and 32nd minutes to crush Ghana hopes.
But the Uruguayans were ultimately also crushed.
Suarez had been substituted when the screen at Al Janoub Stadium suddenly flashed that South Korea was in second place in the group after a late goal against Portugal.
Uruguay surged forward in search of the goal that would have put it through. Substitutes Maximiliano Gomez and Sebastian Coates both missed late chances and Suarez was crying after the final whistle.