Scaroni, a 31-year-old from Illinois, pulled away from the field early and also earned the bonus money for topping the course record. She beat runner-up Manuela Schar of Switzerland by 2 1/2 minutes, and last year's winner, Madison de Rozario of Australia, finished third.
Scaroni won the Chicago Marathon last month and was victorious for the first time in New York after finishing third in 2019.
The 36-year-old Hug, nicknamed the "The Silver Bullet," has been on quite a streak, winning four gold medals at the Tokyo Paralympics last year as well as the Tokyo, Berlin, London and Chicago Marathons in 2022.
It was an unseasonably warm day - with the temperature expected to soar into the 70s and possibly challenge the record for the hottest race since the marathon moved to November in 1986.
This was the first time that the marathon was back to full capacity since the pandemic.