In Siaya county, the demonstrations were led by some local leaders.
Protesters carried placards and twigs while chanting about the high cost of living.
In Migori, demonstrators barricaded major roads with stones and logs. Police were forced to lob teargas canisters to disperse the crowd.
Police in Kisii kept vigil as the residents remained calm despite the mass action call.
Raila maintained that the opposition would continue to push President William Ruto's government to lower the cost of basic commodities saying majority of Kenyans are suffering.
Addressing supporters in Kamkunji, Nairobi, after police diverted his convoy that was headed to the Central Business District, the Azimio leader said the anti-government protests will be held every Monday.
The Opposition leader also alleged that the 2022 General Election was rigged and the IEBC servers were manipulated.
"They must open the IEBC servers; Kenyans want to know the truth. They have messed the economy of Kenya by increasing taxes and prices of basic commodities. Punda amechoka (the donkey is tired)," Raila said while addressing supporters who were chanting unga, unga, unga (flour).
The Azimio leaders convoy made several stops including in Eastleigh where they maintained that their victory was stolen.
Wiper leader Kalonzo Musyoka called for the immediate and unconditional release of a section of Azimio leaders, including Senate Minority Leader Stewart Madzayo and his National Assembly counterpart Opiyo Wandayi, who were being held at the DCI headquarters along Kiambu Road.
Raila was accompanied by Suna East MP Junet Mohammed, former Defence Cabinet Secretary Eugene Wamalwa, Jubilee Secretary General Jeremiah Kioni and Homa Bay Governor Gladys Wanga among other leaders.