President William Ruto is expected to lead the day's celebrations, themed around the blue economy, a sector seen as key to unlocking the country's aquatic potential.
He will be joined by his Deputy Kithure Kindiki, Homa Bay Governor Gladys Wanga, and former Prime Minister Raila Odinga, who are all slated to address the crowd.
This marks the first time Homa Bay County has hosted a national event of this magnitude, shining a spotlight on the region and underlining growing calls for investment in Kenya's water-based economic sectors.
Madaraka Day is marked every 1st of June every year, to commemorate the day in 1963 when the country attained internal self-rule (self-governance) from British colonial rule.