Ghana, which squeezed out a thrilling 3-2 win over South Korea in its last game, must win again in Al Wakrah to be certain of going past the group stage for the first time since 2010. A draw could also be enough depending on the result of South Korea vs. Portugal.
Captain Andre Ayew is the only Ghana player in Qatar who was on the 2010 squad.
Uruguay has a handful, including the 35-year-old Suarez, who is playing what's likely his farewell World Cup before winding down a career that saw him celebrated as one of the best forwards in the world at one point. He won the Copa America with Uruguay and Spanish league titles and a Champions League trophy with Barcelona.
Suarez also carved out a reputation as one of the game's most controversial characters and has also been punished three times for biting opponents, including a four-month ban for biting Italy defender Giorgio Chiellini on the shoulder at the 2014 World Cup in Brazil.
Suarez started Uruguay's 0-0 draw with South Korea in Qatar but was left on the bench for the 2-0 loss to Portugal, which left Uruguay bottom of the group.
Uruguay must now beat Ghana and hope South Korea doesn't beat Portugal to extend its stay at the World Cup and Suarez's international career for at least one more game. Goal difference will decide it if Uruguay and South Korea both win.
Stoking it up just a little, Suarez said the 2010 game against Ghana does still mean something.
"We are going to put our lives and soul into this match," Suarez said. "Ghana is a good team but we know them, we have beaten them before and we know how to beat them again."