Arsene Wenger looks set to hand a start to Danny Welbeck for Thursday night's Europa League clash against Cologne.
Welbeck hasn't featured since Arsenal's 2-1 defeat at Watford last month but is expected to partner the fit-again Olivier Giroud in attack.
With the Gunners already qualified out of Group H for the knockout stage, manager Wenger is expected to again give his young players a chance to impress, with the likes of 17-year-old Reiss Nelson, Ainsley Maitland-Niles, Eddie Nketiah and Joe Willock all expected to feature in the squad.
Wenger said: "We have brought some young players as well who have played in former games and done extremely well. Overall I believe we have a good mix between experience and young players."
Arsenal will be hoping to complete the double over the Bundesliga outfit following their 3-1 victory back at the Emirates in September.
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Predicted starting XI: Ospina, Debuchy, Holding, Mertesacker, Chambers, Maitland-Niles, Coquelin, Elneny, Wilshere, Welbeck, Giroud