Hollywood screenwriter and director Nora Ephron, who penned such films as When Harry Met Sally and Sleepless in Seattle, has died at the age of 71.
Alfred P Knopf, Ephron's publisher, confirmed her death on Tuesday night in a statement.
Her son told the New York Times she died in Manhattan of complications relating to acute myeloid leukaemia.
The writer grew up in California, and started her career reporting for the New York Post.
"She brought an awful lot of people a tremendous amount of joy," her publisher said in a statement. "She will be sorely missed."
Her 15 film credits also include You've Got Mail, Silkwood and Julie and Julia, which was her final film, in 2009.
She was nominated for an Oscar three times, but never won the award.
Ephron was born on 19 May 1941 in New York, to a Broadway playwright and a Hollywood screenwriter.
She put her mother's advice - "take notes, everything is copy" - to good effect, turning wry personal observations on relationships into hugely successful romantic comedies.
Ephron wrote essays for major US magazines from the late 1960s, as well as several non-fiction books, including two recent memoirs.
She was married three times, once to Carl Bernstein, the Washington Post reporter who helped uncover the Watergate scandal.
The marriage ended publicly when he began an affair with the wife of the then-British ambassador, Margaret Jay, who was also the daughter of former British Prime Minister James Callaghan.